Phase III Studies and Guideline Recommendations*
* In Hong Kong, TS-ONE ® is indicated for post operative adjuvant chemotherapy for locally advanced (stage II (excluding T1), IIIA or IIIB) gastric cancer
Pancreatic Cancer
- Motoi F et al., 2019. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/ JSAP-05).
Jpn J Clin Oncol., 49(2), pp.190-194. - Okusaka T. et al. 2020 Clinical Practice Guidelines for Pancreatic Cancer 2019 From the Japan Pancreas Society: A Synopsis.
Pancreas. 2020 Mar; 49(3):326-335 - Uesaka K et al., 2016. Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label randomised, non-inferiority trial (JASPAC 01).
Lancet, 388(10041), pp.248-257. - Ueno H et al., 2013. Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study.
J Clin Oncol., 31(13), pp.1640-1648.
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